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3 edition of Pharmacological investigation of cholecystokinin (CCK) receptors involved in suppression of food intake by intestinal nutrients found in the catalog.

Pharmacological investigation of cholecystokinin (CCK) receptors involved in suppression of food intake by intestinal nutrients

Lynne Anne Brenner

Pharmacological investigation of cholecystokinin (CCK) receptors involved in suppression of food intake by intestinal nutrients

by Lynne Anne Brenner

  • 268 Want to read
  • 25 Currently reading

Published .
Written in English

    Subjects:
  • Cholecystokinin -- Receptors,
  • Ingestion -- Regulations

  • Edition Notes

    Statementby Lynne Anne Brenner.
    GenreRegulations.
    The Physical Object
    Paginationxi, 95 leaves, bound :
    Number of Pages95
    ID Numbers
    Open LibraryOL16981945M
    OCLC/WorldCa33879627

    Preliminary investigation of the pharmacology of the human internal anal sphincter. Gut, 10, – PubMed PubMedCentral CrossRef Google Scholar Paton, W. D. M. (). Cholecystokinin (CCK or CCK-PZ; from Greek chole, "bile"; cysto, "sac"; kinin, "move"; hence, move the bile-sac (gallbladder)) is a peptide hormone of the gastrointestinal system responsible for stimulating the digestion of fat and ystokinin, officially called pancreozymin, is synthesized and secreted by enteroendocrine cells in the duodenum, the first segment of the small intestine.

      Cholecystokinin (CCK) is a regulatory peptide hormone, predominantly found in the gastrointestinal tract, and a neurotransmitter present throughout the nervous system. In the gastrointestinal system CCK regulates motility, pancreatic enzyme secretion, gastric emptying, and gastric acid secretion. Part of the Handbook of Experimental Pharmacology book series (HEP, volume ) Abstract Although the basic structure of the gastrointestinal tract (GIT) is similar across species, there are significant differences in the anatomy, physiology, and biochemistry between humans and laboratory animals, which should be taken into account when.

    Secretin, Cholecystokinin, Pancreozymin and Gastrin: A Sourcebook of Methods and Techniques (Handbook of Experimental Pharmacology): Medicine & Health Science Books @ . Ensembl ENSG ENSMUSG UniProt P O RefSeq (mRNA) NM_ NM_ NM_ RefSeq (protein) NP_ NP_ NP_ Location (UCSC) Chr 4: – Mb Chr 5: – Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Cholecystokinin A receptor, N-terminal domain molecular complex of cholecystokinin .


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Pharmacological investigation of cholecystokinin (CCK) receptors involved in suppression of food intake by intestinal nutrients by Lynne Anne Brenner Download PDF EPUB FB2

Pharmacological Investigations of the Cellular Transduction Pathways Used by Cholecystokinin to Activate Nodose Neurons Huan Zhao, Dallas C. Kinch, and Steven M. Simasko Program in Neuroscience, Dept of Veterinary and Comparative Anatomy, Pharmacology, and Physiology Washington State University, Pullman, WA Cited by: 5.

1. Introduction. Nutrient induced release of cholecystokinin (CCK) from I cells in the small intestine acts to facilitate efficient gastrointestinal function and promotes the process of satiation (Gibbs et al., ).CCK-induced satiation is attenuated or abolished by surgical (Smith et al., ) or chemical (Ritter and Ladenheim, ) ablation of the afferent vagus; consistent with a local Cited by: 5.

Pharmacological Investigations of the Cellular Transduction Pathways Used by Cholecystokinin to Activate Nodose Neurons Article in Autonomic neuroscience: basic & clinical () June. Seok Jun Moon, Jeong Mi An, Juyeon Kim, Syng-Ill Lee, Wooin Ahn, Kyung Hwan Kim and Jeong Taeg Seo, Pharmacological characterization of rebamipide: its cholecystokinin CCK1 receptor binding profile and effects on Ca2+ mobilization and amylase release in rat pancreatic acinar cells, European Journal of Pharmacology, / Cited by:   Therefore, it is hard to investigate the pharmacological mechanisms of ZJW in the treatment of gastritis.

With the rapid progress of bioinformatics, systems biology and polypharmacology, network pharmacology-based approaches have been proven to be a powerful way for compatible and mechanistic exploration of TCM formula [7, 11, 12].Cited by:   1.

Introduction. Cholecystokinin (CCK) receptors were originally classified into two subtypes, CCK 1 and CCK 2, on the basis of differences in agonist rank potency orders and through the use of receptor-selective of these receptor subtypes can mediate the contraction of gastrointestinal (GI) tissues.

Zuojinwan (ZJW), a classic herbal formula, has been extensively used to treat gastric symptoms in clinical practice in China for centuries. However, the pharmacological mechanisms of ZJW still remain vague to date.

In the present work, a network pharmacology-based strategy was proposed to elucidate its underlying multi-component, multi-target, and multi-pathway mode of action against gastritis. Evans BE, Rittle KE, Bock MG, DiPardo RM, Freidinger RM, Whitter WL, et al. Methods for drug discovery: Development of potent, selective, orally effective cholecystokinin antagonists.

Journal of Medicinal Chemistry. ;31(12) Cryan JF, Sweeney FF. The age of anxiety: Role of animal models of anxiolytic action in drug discovery. This review will highlight the results from both basic and clinical investigations that have examined the effects of selective CCK receptor ligands.

The focus will be on the central nervous system pharmacology of CCK antagonists and the involvement of CCK in gastrointestinal and colonic motility. To date the pharmacological and physiological investigations of the roles of these receptors has been hampered by the lack of sufficiently selective antagonists for each receptor.

However, new compounds are now being produced with much greater selectivity than has been attained before. The cholecystokinin 2 (CCK2, formerly CCKB) receptor is a guanine nucleotide coupled receptor (GPCR) that mediates the effects of the peptide hormones gastrin and cholecystokinin.

The physiological responses to CCK2 receptor activation include gastric acid secretion, growth of gastrointestinal mucosa, along with effects on satiety and anxiety.

Behar J, Biancani P. Effect of cholecystokinin and the octapeptide of cholecystokinin on the feline sphincter of Oddi and gallbladder. Mechanisms of action. J Clin Invest. Dec; 66 (6)– [PMC free article] Bennett A. Relationship between in-vitro studies of gastrointestinal muscle and motility of the alimentary tract in vivo.

The cholecystokinin-B and gastrin receptor is encoded by a single gene composed of five exons and spanning over 10 kilobases on human chromosome 11p > Cholecystokinin (CCK) is a neurotransmitter found in high density in the brains of mammals.

This paper reviews phases of investigations which studied the validity of CCK4 as a panicogenic agent and research strategies for the study of panic disorder using CCK4 as an investigative tool. Full text pharmacological identification.

Peristaltic stimulant—Cholecystokinin increases muscle contractions of the stomach and small intestine. {01} {03} {09} {11} {19} {23} {24} Other actions/effects: Cholecystokinin inhibits contraction of the lower esophageal sphincter and the sphincter of Oddi.

{01} {03} {09} {11} Onset of action: Contraction of the gallbladder—Within 1 to 3. Pharmacological investigations of the cellular transduction pathways used by cholecystokinin to activate nodose neurons. Auton Neurosci.

; () (ISSN: ) Zhao H; Kinch DC; Simasko SM. Cholecystokinin (CCK) directly activates vagal afferent neurons resulting in coordinated gastrointestinal functions and satiation. The book contains chapters on the synthesis, biochemical and pharmacological characterization of potent and selective CCK antagonists as well as physiological applications of these compounds.

The last section of the book is devoted to the involvement of CCK in pathological states and potential clinical applications of CCK antagonists. Cholecystokinin (CCK) acts acutely to inhibit food consumption in fasted rats1–4, mice5–7, sheep8, pigs9, monkeys10 and humans11– CCK has been proposed as a satiety signal, inducing the.

Abstract. In order to study the mechanisms influencing bile acid pool size and cholesterol saturation index of fasting gall bladder bile, eight obese volunteers were placed on a low calorie diet for six weeks, and given intramuscular injections of a pharmacological dose of cholecystokinin octapeptide (CCK-OP, 5 micrograms) at mealtimes for half that period (alternating order).

Neurochemical investigation of the afferent pathway from the vagus nerve to the nucleus tractus solitarius in mediating the “satiety syndrome” induced by systemic cholecystokinin Article Feb. Chang, RSL & Lotti, VJ () Biochemical and pharmacological characterization of an extremely potent and selective nonpeptide cholecystokinin antagonist.

Proceedings of the National Academy of Sciences – Intrathecal (ith) injection of cholecystokinin octapeptide (CCK-8) to the rat with single dose of 4 or 40 ng, or successive doses from to 1 microgram at 10 min intervals produced neither.J. Med. Chem. All Publications/Website.

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